It should be said that the issue I highlighted regarding the potential for creating a differential grind, need not be negative as long as you're making it work for you. By positioning the clamp in a certain way, you can differ the profile at the forte and foible with a smooth transition in-between, depending on what work you're doing. I have knives that have a sharper piercing tip, and others where the tip is more robust, whilst the forte is sharper for finer work such as whittling.

The only consistent feature of clamped systems, is that it tends to give you a secondary grind rather than an appleseed profile.